Psychopathological disorders in patients with ischemic stroke

Background. Psychopathological disorders in patients who have suffered ischemic stroke can often be no less significant than neurological deficits, complicating recovery and worsening the prognosis of the disease. Such disorders include disorders of sensation, perception, attention, thinking, intelligence, emotional-volitional and motor spheres, consciousness and others. Purpose – to analyze current literary sources on the prevalence, anatomical, neurobiological and pathophysiological mechanisms of the development of psychopathological disorders that accompany ischemic stroke and their impact on recovery and prognosis. To expand the understanding of the most common psychopathological disorders, in particular post-stroke depression, apathy, neglect syndrome in cerebral infarction and their clinical and neurological course and neuropsychological signs. Materials and Methods. The article presents a bibliographic systematic review of data from PubMed, Scopus and Web of Science databases on all known psychopathological disorders in patients who have suffered a cerebral infarction, their anatomical features, mechanisms of development, course and impact on the consequences of the underlying disease. Results. A literature search and analysis of the anatomical, neurobiological and pathophysiological mechanisms of the development of numerous psychopathological disorders accompanying ischemic stroke were conducted. The main structural lesions were identified, in particular changes in neurotransmitter regulation and dysfunction of various cortical areas. Post-stroke depression, anxiety and neglect remain among the most common complications, which are often comorbid and negatively affect the restoration of physical functions during rehabilitation. Timely diagnosis and treatment of such disorders will contribute to improving the consequences of stroke and the quality of life of such patients. Conclusions. Further research should be aimed at developing effective screening diagnostic methods that will allow for timely intervention and improve rehabilitation outcomes in the development of psychopathological disorders in patients with ischemic stroke.