Clinicopathologic Features, Molecular Landscape, and Prognostic Implications of Ovarian Low-grade Serous Tumors with Histologic Transformation
LGS-HT exhibit both low-grade and high-grade morphologic and molecular features, representing an exception to the dualistic classification of ovarian serous neoplasms. The presence of a definitive high-grade carcinoma component in a low-grade serous tumor portends aggressive clinical behavior.
Authors
- Alexia Iasonos (ORCID: https://orcid.org/0000-0003-0471-8477)
- Sarah Chiang (ORCID: https://orcid.org/0000-0001-9698-0936)
- Pier Selenica (ORCID: https://orcid.org/0000-0003-0086-0513)
- M. Herman Chui (ORCID: https://orcid.org/0000-0002-7220-3996)
- Beryl Manning‐Geist (ORCID: https://orcid.org/0000-0002-5556-0457)
- Rachel N. Grisham (ORCID: https://orcid.org/0000-0002-8631-9324)
- Britta Weigelt (ORCID: https://orcid.org/0000-0001-9927-1270)
- Qin Zhou (ORCID: https://orcid.org/0000-0003-1225-2902)
- Eun-Young Kang
- Arnaud Da Cruz Paula (ORCID: https://orcid.org/0000-0001-7694-8760)
- Kara Long Roche (ORCID: https://orcid.org/0000-0003-0342-2922)
- Ryan Kahn (ORCID: https://orcid.org/0000-0002-5596-6238)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3168
- Citations
- 5
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 8.49
Funders
- National Institutes of Health