Inhibition of Thioredoxin Reductase Activity and Oxidation of Cellular Thiols by Antimicrobial Agent, 2-Bromo-2-nitro-1,3-propanediol, Causes Oxidative Stress and Cell Death in Cultured Noncancer and Cancer Cells
These findings highlight BP's potential as a TrxR inhibitor and its cytotoxicity toward both noncancer and cancer cells. The observed effects-TrxR inhibition, thiol oxidation, GSH/GSSG imbalance, and ROS accumulation-may underlie BP's cytotoxicity. Further research is needed to explore the precise molecular mechanisms by which BP exerts these effects.
Authors
- Gary Krzyzanowski
- Dinesh S. Chandel (ORCID: https://orcid.org/0000-0002-0424-9423)
- Appolinaire Olou (ORCID: https://orcid.org/0000-0002-6754-2969)
- Wesley A. Tom (ORCID: https://orcid.org/0000-0002-5951-5311)
- Chao Jiang (ORCID: https://orcid.org/0000-0003-2801-0086)
- M. Rohan Fernando (ORCID: https://orcid.org/0000-0002-3596-3160)
- Nirmalee Fernando
Institutions
- Boys Town (US)
- Boys Town National Research Hospital (US)
Publication Details
- Journal
- Biology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.3390/biology14050509
- Citations
- 1
- Primary Topic
- Redox biology and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.81