Global burden of ischemic stroke in middle-aged workforce population, 1990-2021: systematic analysis of the Global Burden of Disease Study 2021

Despite overall reductions in stroke burden, ischemic stroke remains a significant public health issue, especially in men and high-middle SDI regions. Effective control of major risk factors like high blood pressure, high LDL cholesterol, and smoking is crucial. Customized prevention programs based on regional and economic contexts are essential to address this persistent health challenge.