Alteration in Indole Metabolites After Cardiopulmonary Bypass Surgery in Neonates and Infants
CPB was associated with significant changes in indole metabolite levels postoperatively. Indole-3-carboxylic acid, which suppresses T-regulatory (Treg) differentiation, is associated with improved patient outcomes, whereas other metabolites, that promote Treg differentiation, were associated with worse outcomes.
Authors
- Tanner Lehmann
- Peter M. Mourani (ORCID: https://orcid.org/0000-0002-1829-3775)
- Sierra Niemiec (ORCID: https://orcid.org/0000-0001-9868-0654)
- Matthew K. Leroue (ORCID: https://orcid.org/0000-0001-7585-7920)
- Aline B. Maddux (ORCID: https://orcid.org/0000-0002-0949-4284)
- Christopher A Mancuso (ORCID: https://orcid.org/0000-0003-3081-2758)
- Ludmila Khailová
- Jesse A Davidson (ORCID: https://orcid.org/0000-0001-9193-9803)
- Jelena Klawitter (ORCID: https://orcid.org/0000-0003-1893-6141)
Institutions
- Arkansas Children's Hospital (US)
- University of Denver (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Critical Care Explorations
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1097/cce.0000000000001267
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00