Genome-wide DNA methylation status as a biomarker for clinical outcomes of first-line treatment in patients with RAS wild-type metastatic colorectal cancer: JACCRO CC-13AR
GWMS was associated with survival in RAS wild-type mCRC patients treated with initial chemotherapy. Also, it may serve as a predictor for selection of molecular-targeted antibodies in first-line treatment.
Authors
- M. Kochi
- Tomoya Sagawa (ORCID: https://orcid.org/0000-0003-3048-0319)
- Wataru Ichikawa (ORCID: https://orcid.org/0000-0001-5543-4488)
- Yu Sunakawa (ORCID: https://orcid.org/0000-0002-0163-7543)
- Hisatsugu Ohori
- A. Tsuji
- Toru Miyake (ORCID: https://orcid.org/0000-0003-0947-0116)
- Toshiaki Kawai
- D. Manaka
- Chikashi Ishioka
- Tatsuro Yamaguchi (ORCID: https://orcid.org/0000-0001-8454-1995)
- Hideo Ôta (ORCID: https://orcid.org/0000-0002-8363-4265)
- M. Shiozawa
- Hisateru Yasui (ORCID: https://orcid.org/0000-0001-5563-5802)
- Kota Ouchi (ORCID: https://orcid.org/0000-0002-5572-1337)
- A. Makiyama
- Masashi Fujii (ORCID: https://orcid.org/0000-0002-5371-9946)
- M. Takeuchi
- M. Matsuura
Institutions
- Nihon University (JP)
- St. Marianna University School of Medicine (JP)
- Kagawa University (JP)
- Kanagawa Prefectural Hospital Organization (JP)
- Tokyo Metropolitan Komagome Hospital (JP)
- Kobe Medical Center (JP)
- Tohoku University Hospital (JP)
- Shiga University of Medical Science Hospital (JP)
- Ikeda Municipal Hospital (JP)
- National Hospital Organization Hokkaido Medical Center (JP)
- Gifu University Hospital (JP)
- Sendai Medical Center (JP)
- Himeji Red Cross Hospital (JP)
- Kyoto Katsura Hospital (JP)
- Japan Clinical Cancer Research Organization (JP)
- SHOWA Medical University Fujigaoka Hospital (JP)
- Sendai Shakai Hoken Hospital (JP)
- Kobe City Medical Center General Hospital (JP)
- Sapporo National Hospital (JP)
- Kanagawa Cancer Center
- The University of Tokyo (JP)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105076
- Citations
- 1
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- AstraZeneca
- Incyte
- Astellas Pharma
- Shionogi
- Astellas Foundation for Research on Metabolic Disorders
- Yakult Honsha
- Chugai Pharmaceutical
- Eli Lilly Japan
- Daiichi Sankyo Europe