Recurrence of acute allergic asthma depends on the role of ILC2 driven by Il1rl1 signaling
The recurrence of acute allergic asthma is driven, at least in part, by ILC2s through Il1rl1 signaling. Genetic ablation of Il1rl1 significantly suppresses asthma relapse, suggesting that targeting Il1rl1 may represent a novel therapeutic strategy for preventing asthma exacerbations.
Authors
- Baoqing Sun (ORCID: https://orcid.org/0000-0002-1671-0723)
- Qingjun Pan (ORCID: https://orcid.org/0000-0002-8060-9099)
- Hui Gan (ORCID: https://orcid.org/0000-0002-4960-1507)
- Zheng Zhu (ORCID: https://orcid.org/0000-0002-6949-3785)
- Zhifeng Huang (ORCID: https://orcid.org/0000-0001-5975-0672)
- Fei Ye
Institutions
- Wuhan University (CN)
- Guangzhou Experimental Station (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Zhongshan People's Hospital (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s12964-025-02220-0
- Citations
- 1
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China