Gut microbiota dysbiosis orchestrates vitiligo-related oxidative stress through the metabolite hippuric acid
Our results suggested the important role of gut microbiota in regulating vitiligo phenotypes and oxidative stress. We identified hippuric acid, a gut microbiota-host co-metabolite, as a critical mediator of oxidative stress in vitiligo skin and its binding targets (NOS2 and MAPK14), resulting in oxidative stress. Validation in a small human cohort suggested that hippuric acid could serve as a novel diagnostic biomarker and therapeutic target for vitiligo. These findings provided new insights into how gut microbiota regulates skin oxidative stress in vitiligo and suggested potential treatment strategies for the disease. Video Abstract.
Authors
- Ye Huang (ORCID: https://orcid.org/0000-0001-7319-7842)
- Yueqi Chen (ORCID: https://orcid.org/0000-0001-6975-2874)
- Xiao‐Ying Yuan
- Weijie Gu
- Xia Lin (ORCID: https://orcid.org/0000-0002-2975-1532)
- Meng Nian (ORCID: https://orcid.org/0009-0007-1159-4974)
- Yijin Wang (ORCID: https://orcid.org/0000-0002-3700-1766)
- Jing Huang (ORCID: https://orcid.org/0000-0002-2090-3958)
- Shengxi Wu (ORCID: https://orcid.org/0000-0002-3210-9567)
- Hong Cai (ORCID: https://orcid.org/0000-0002-7388-747X)
- Qingrong Ni
Institutions
- Army Medical University (CN)
- General Hospital of Shenyang Military Region (CN)
- Southwest Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s40168-025-02102-0
- Citations
- 6
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 6.91
Funders
- National Natural Science Foundation of China