USE OF TECHNOLOGY OF CRYODESTRUCTION OF PLANT RAW MATERIALS AND STUDY OF THE THERAPEUTIC EFFECTIVENESS OF THE VETERINARY PREPARATION "AKARO SPECTRA" (ANTI-PARASITIC TABLETS FOR DOGS)

The article provides data on the creation of a new preparation "Akaro Spectra" (antiparasitic tablets for dogs) using the technology of cryodestruction of plant raw materials and determining its effectiveness against endoparasites of dogs. Cryodestruction is based on ultra-rapid freezing of plant products to remove water from tissues by physical or osmotic dehydration. Many external and internal parasites are recorded in dogs. The most common are the ixodid mites (Ixodes ricinis, Rhipicephalus sanguineus, Dermacentor reticulatis), sarcoptic mange mites (Otodectes cynotis, Notoedres cati, Sarcoptes canis) and thrombidiform mites (Demodex spp., Cheyletiella spp.). Various efforts are being made to develop environmentally safe and cost-effective acaricidal preparations. The goal of the work: to determine in vitro insecto-acaricidal and ovocidal efficacy of the veterinary medicinal product "Akaro Spectra" (antiparasitic tablets for dogs) against ixodid and sarcoptic ticks. The test animals were selected by clinical assessment for skin lesions such as dermatitis, alopecia and the degree of skin health. The number of adult fleas on the animal was counted using a fine-toothed comb (11–13 teeth/cm) by combing the entire body for 5–20 min depending on the required accuracy or until fleas were caught after 50 strokes. The effectiveness of the treatment was determined after 1, 2, 3, 7, 14, 21 and 28 days by examining the skin and hair. The developed phytocomplex includes kelp (Laminaria), neem leaves (Azadirachta indica), garlic (Allium sativum) and lemon balm (Melissa officinalis), which act together to repel common parasites. Before the use of the drug, the average intensity of infestation by Otodectes cynotis ticks was 91.3±10.5 specimens/head, and by Ixodes ticks - 22.5±3.7 specimens/head. During the first day, the drug demonstrated efficacy against O. cynotis at 65.8% with an average infestation of 31.2±6.5 specimens/head. On the second day, the efficacy was 100%. As for ticks Ixodes spp., Dermacentor spp. and Rhipicephalus spp., on the second day of the study, the efficacy of the drug was 93.76% with an average infestation of 1.5±0.3 specimens/head.