The impact of carboplatin on pathologic complete response and survival based on HER2 low and HER2 zero status in triple negative breast cancer patients receiving neoadjuvant chemotherapy: a multicenter real-world analysis
Our research demonstrates that the addition of carboplatin increases pCR rates in both HER2-zero and HER2-low patient cohorts. We suggest that carboplatin should be considered as an addition to standard neoadjuvant chemotherapy for eligible TNBC patients, regardless of HER2-zero or HER2-low status, when appropriate based on individual patient factors and toxicity considerations.
Authors
- Mesut Yılmaz (ORCID: https://orcid.org/0000-0003-1466-3887)
- Özkan Alan (ORCID: https://orcid.org/0000-0002-6635-2012)
- Nargız Majidova (ORCID: https://orcid.org/0000-0002-2575-5819)
- Ali Alper Solmaz (ORCID: https://orcid.org/0000-0003-4696-1723)
- Mahmut Emre Yıldırım (ORCID: https://orcid.org/0000-0002-5360-5949)
- Heves Sürmeli (ORCID: https://orcid.org/0000-0003-1604-8466)
- Özlem Nuray Sever (ORCID: https://orcid.org/0000-0003-3462-9360)
- Ömer Saçlı (ORCID: https://orcid.org/0000-0001-7836-139X)
- Oğuzcan Kınıkoğlu (ORCID: https://orcid.org/0000-0001-5983-3291)
- Nedim Turan (ORCID: https://orcid.org/0000-0002-1140-8779)
- Tuğba Başoğlu (ORCID: https://orcid.org/0000-0002-2059-5502)
- Goncagül Akdağ (ORCID: https://orcid.org/0000-0002-6221-0623)
- Alper Topal (ORCID: https://orcid.org/0000-0002-9679-9245)
- Timuçin Çil (ORCID: https://orcid.org/0000-0002-5033-1479)
- Serhat Sekmek (ORCID: https://orcid.org/0000-0003-4650-248X)
- Sedat Yıldırım (ORCID: https://orcid.org/0000-0002-2423-6902)
- Mustafa Gürbüz (ORCID: https://orcid.org/0000-0001-7680-4142)
- Kubilay Karaboyun (ORCID: https://orcid.org/0000-0002-1783-8075)
- Akif Doğan (ORCID: https://orcid.org/0000-0003-4275-2414)
- Rumeysa Çolak (ORCID: https://orcid.org/0000-0002-3867-0793)
- Melike Özçelik (ORCID: https://orcid.org/0000-0003-0406-715X)
- Hatice Odabaş (ORCID: https://orcid.org/0000-0002-5757-4705)
- Deniz Işık (ORCID: https://orcid.org/0000-0003-4398-5148)
- Ali̇ Kalem
- Nadiye Sever
Institutions
- Ministry of Health (TR)
- Koç University (TR)
- Gülhane Askerî Tıp Akademisi (TR)
- Memorial Ankara Hospital (TR)
- Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi (TR)
- Ümraniye Eğitim ve Araştırma Hastanesi (TR)
- Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Gaziantep University (TR)
- Marmara University (TR)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s12885-025-14252-3
- Citations
- 1
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05