Chagas Meningoencephalitis Diagnosed in Heart Transplant Patient Using Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid
Chagas meningoencephalitis can present in immunocompromised patients after organ transplantation. We present the first reported instance in which metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid diagnosed Chagas meningoencephalitis in a patient. The diagnosis of Chagas in this case underscores the role of mNGS in identifying rare or unexpected pathogens.
Authors
- Christina Coyle (ORCID: https://orcid.org/0000-0001-9565-3087)
- Vagish Hemmige (ORCID: https://orcid.org/0009-0006-6346-1826)
- Rita Jermyn (ORCID: https://orcid.org/0000-0001-7249-7755)
- Charles Y. Chiu (ORCID: https://orcid.org/0000-0003-2915-2094)
- Snehal R. Patel (ORCID: https://orcid.org/0000-0003-4987-051X)
- Shivank Madan (ORCID: https://orcid.org/0000-0003-0613-1522)
- Jill Teitelbaum
- Phyu M. Thwe (ORCID: https://orcid.org/0000-0003-3250-9998)
- Mayuko Uehara
Institutions
- Albert Einstein College of Medicine (US)
- Montefiore Medical Center (US)
- University of California, San Francisco (US)
Publication Details
- Journal
- American Journal of Tropical Medicine and Hygiene
- Published
- 2025-05-06
- DOI
- https://doi.org/10.4269/ajtmh.24-0553
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 0.00