Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Targeting cancer-specific variants with CRISPR/Cas9-nickase induces cancer-specific cell death in combination with DNA repair pathway inhibitors, demonstrating the potential of CRISPR cancer therapy for treating a broad range of cancers.

Authors

Institutions

Publication Details

Journal
Cancer Research
Published
2025-05-06
DOI
https://doi.org/10.1158/0008-5472.can-24-2938
Citations
2
Primary Topic
CRISPR and Genetic Engineering
Type
article
Field-Weighted Citation Impact
1.61

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Joo Hee Kang, M. Ryan Corces, In Ho Song, Hye‐Jin Jeong et al.
2 citations
Cancer Research
CRISPR and Genetic Engineering
1.61
article

Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

Joo Hee Kang, M. Ryan Corces, In Ho Song, Hye‐Jin Jeong, Yoon Ji Choi, Minjong Kim, Euihwan Jeong, Heon Seok Kim, Tae‐Eun Park, Seon‐gyeong Lee, Kyungjae Myung, Soyoung Lee, Kayeong Lim, Himchan Cheng, Jinmyoung Joo, Eun A Lee, Taejoon Kwon, Chang Sik Yu, Deok‐Beom Jung, Kyunghwan Kim, Dayoung Kim, Seung Woo Cho, Jinhee Mun, Seung‐Jae Myung, Subin Choi, Yewon Jang, Eunjin Lee, Soomin Heo
article en
2 citations

Abstract

Targeting cancer-specific variants with CRISPR/Cas9-nickase induces cancer-specific cell death in combination with DNA repair pathway inhibitors, demonstrating the potential of CRISPR cancer therapy for treating a broad range of cancers.

Cancer ResearchVol. 85(15)
Ulsan College (KR), CURE International UK (GB), Gladstone Institutes (US), University of California, San Francisco (US), Asan Medical Center (KR), University of Ulsan (KR), STR Biotech (South Korea) (KR), Institute for Basic Science (KR), Io Therapeutics (United States) (US), Hanyang University (KR), Ulsan National Institute of Science and Technology (KR), Korea Institute of Science and Technology (KR), Korea Institute of Science & Technology Information (KR)
POSCO TJ Park Foundation, Ulsan National Institute of Science and Technology, Ministry of Health and Welfare, National Research Foundation of Korea, Institute for Basic Science, Ministry of Science and ICT, South Korea
Good health and well-being
Openalex Percentile: Top 17%
CRISPR and Genetic Engineering
1.61
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.