Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells
Targeting cancer-specific variants with CRISPR/Cas9-nickase induces cancer-specific cell death in combination with DNA repair pathway inhibitors, demonstrating the potential of CRISPR cancer therapy for treating a broad range of cancers.
Authors
- Joo Hee Kang (ORCID: https://orcid.org/0000-0001-9636-3209)
- M. Ryan Corces (ORCID: https://orcid.org/0000-0001-7465-7652)
- In Ho Song (ORCID: https://orcid.org/0000-0002-7932-6163)
- Hye‐Jin Jeong (ORCID: https://orcid.org/0009-0004-7458-654X)
- Yoon Ji Choi
- Minjong Kim (ORCID: https://orcid.org/0009-0001-5168-2211)
- Euihwan Jeong (ORCID: https://orcid.org/0009-0006-0141-5293)
- Heon Seok Kim (ORCID: https://orcid.org/0000-0002-5981-3511)
- Tae‐Eun Park (ORCID: https://orcid.org/0000-0003-3979-5405)
- Seon‐gyeong Lee (ORCID: https://orcid.org/0000-0002-7770-2073)
- Kyungjae Myung (ORCID: https://orcid.org/0000-0001-7975-6190)
- Soyoung Lee (ORCID: https://orcid.org/0000-0001-5719-0149)
- Kayeong Lim (ORCID: https://orcid.org/0000-0002-6274-7252)
- Himchan Cheng (ORCID: https://orcid.org/0000-0001-5950-6995)
- Jinmyoung Joo (ORCID: https://orcid.org/0000-0003-1574-9842)
- Eun A Lee (ORCID: https://orcid.org/0000-0002-5463-8451)
- Taejoon Kwon (ORCID: https://orcid.org/0000-0002-9794-6112)
- Chang Sik Yu (ORCID: https://orcid.org/0000-0001-9401-9981)
- Deok‐Beom Jung (ORCID: https://orcid.org/0000-0003-4314-6643)
- Kyunghwan Kim (ORCID: https://orcid.org/0000-0002-3786-2697)
- Dayoung Kim (ORCID: https://orcid.org/0000-0002-7221-2446)
- Seung Woo Cho (ORCID: https://orcid.org/0000-0001-9091-0937)
- Jinhee Mun (ORCID: https://orcid.org/0000-0003-0745-0023)
- Seung‐Jae Myung (ORCID: https://orcid.org/0000-0003-0585-4016)
- Subin Choi (ORCID: https://orcid.org/0009-0002-1947-9966)
- Yewon Jang (ORCID: https://orcid.org/0000-0003-2339-7760)
- Eunjin Lee (ORCID: https://orcid.org/0000-0001-7553-5630)
- Soomin Heo (ORCID: https://orcid.org/0009-0006-8036-4331)
Institutions
- Ulsan College (KR)
- CURE International UK (GB)
- Gladstone Institutes (US)
- University of California, San Francisco (US)
- Asan Medical Center (KR)
- University of Ulsan (KR)
- STR Biotech (South Korea) (KR)
- Institute for Basic Science (KR)
- Io Therapeutics (United States) (US)
- Hanyang University (KR)
- Ulsan National Institute of Science and Technology (KR)
- Korea Institute of Science and Technology (KR)
- Korea Institute of Science & Technology Information (KR)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1158/0008-5472.can-24-2938
- Citations
- 2
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- POSCO TJ Park Foundation
- Ulsan National Institute of Science and Technology
- Ministry of Health and Welfare
- National Research Foundation of Korea
- Institute for Basic Science
- Ministry of Science and ICT, South Korea