The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer

The integrated stress response represents a targetable axis to improve the efficacy of immunotherapy in lung cancer by inhibiting the coordinated translational regulation of the PD-L1/PD-1 and CD155/TIGIT immune checkpoint pathways.

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Publication Details

Journal
Cancer Research
Published
2025-05-06
DOI
https://doi.org/10.1158/0008-5472.can-24-3844
Citations
5
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
5.23

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article

The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer

Wei Lü, Esra A. Akbay, Shayna Thomas-Jardin, Lisa Thomas et al.
5 citations
Cancer Research
Cancer Immunotherapy and Biomarkers
5.23
article

The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer

Wei Lü, Esra A. Akbay, Shayna Thomas-Jardin, Lisa Thomas, Khaja Khan, Ariana Arce, Shruthy Suresh, Maria E. Salvatierra, Chul Ahn, Nicole Novaresi, Ignacio I. Wistuba, Cheryl M. Lewis, John D. Minna, Kathryn A. O’Donnell, Emily Stein, Bret M. Evers, Luisa M. Solis Soto, Qing Deng
article en
5 citations

Abstract

The integrated stress response represents a targetable axis to improve the efficacy of immunotherapy in lung cancer by inhibiting the coordinated translational regulation of the PD-L1/PD-1 and CD155/TIGIT immune checkpoint pathways.

Cancer ResearchVol. 85(14)
The University of Texas MD Anderson Cancer Center (US), Institute of Genomics and Integrative Biology (IN), Southwestern Medical Center (US), The University of Texas Southwestern Medical Center (US), Academy of Scientific and Innovative Research (IN)
U.S. Department of Defense, Welch Foundation, V Foundation for Cancer Research, Melanoma Research Foundation, Cancer Prevention and Research Institute of Texas, National Cancer Institute
Good health and well-being
Openalex Percentile: Top 4%
Cancer Immunotherapy and Biomarkers
5.23
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