The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
The integrated stress response represents a targetable axis to improve the efficacy of immunotherapy in lung cancer by inhibiting the coordinated translational regulation of the PD-L1/PD-1 and CD155/TIGIT immune checkpoint pathways.
Authors
- Wei Lü (ORCID: https://orcid.org/0000-0003-4159-3861)
- Esra A. Akbay (ORCID: https://orcid.org/0000-0002-4149-2529)
- Shayna Thomas-Jardin (ORCID: https://orcid.org/0000-0002-2412-7562)
- Lisa Thomas
- Khaja Khan
- Ariana Arce (ORCID: https://orcid.org/0009-0006-8602-686X)
- Shruthy Suresh (ORCID: https://orcid.org/0000-0002-2985-8284)
- Maria E. Salvatierra
- Chul Ahn (ORCID: https://orcid.org/0000-0002-2997-9203)
- Nicole Novaresi (ORCID: https://orcid.org/0000-0001-7890-4382)
- Ignacio I. Wistuba (ORCID: https://orcid.org/0000-0003-3365-6340)
- Cheryl M. Lewis (ORCID: https://orcid.org/0000-0003-2685-6475)
- John D. Minna (ORCID: https://orcid.org/0000-0002-7776-0767)
- Kathryn A. O’Donnell (ORCID: https://orcid.org/0000-0003-2215-1064)
- Emily Stein (ORCID: https://orcid.org/0009-0008-0698-4414)
- Bret M. Evers (ORCID: https://orcid.org/0000-0001-5686-0315)
- Luisa M. Solis Soto (ORCID: https://orcid.org/0000-0002-1253-630X)
- Qing Deng (ORCID: https://orcid.org/0000-0001-9835-6889)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Institute of Genomics and Integrative Biology (IN)
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3844
- Citations
- 5
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 5.23
Funders
- U.S. Department of Defense
- Welch Foundation
- V Foundation for Cancer Research
- Melanoma Research Foundation
- Cancer Prevention and Research Institute of Texas
- National Cancer Institute