Autophagy-induced osteoblast-derived exosomes maintain bone formation and prevent osteoporosis by remodeling gut microbiota-metabolism
Our findings demonstrated that Auto-exo promoted bone formation by modulating the gut microbiota-metabolite bilirubin axis, thereby alleviating osteoporosis progression. This discovery provides a novel perspective on the mechanism underlying the therapeutic effects of Auto-exo on osteoporosis.
Authors
- Chuandong Fan (ORCID: https://orcid.org/0000-0003-0584-4539)
- Yongde Peng (ORCID: https://orcid.org/0000-0001-9388-4922)
- You Li (ORCID: https://orcid.org/0000-0003-3686-9691)
- Lin Chen (ORCID: https://orcid.org/0000-0001-8530-2363)
- Ling Pan (ORCID: https://orcid.org/0000-0002-4572-5609)
- Yufan Wang (ORCID: https://orcid.org/0000-0001-9614-3986)
- Xiaonan Zhu
- Liesheng Lu
- Shanshan Tang (ORCID: https://orcid.org/0000-0001-5264-544X)
Institutions
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Chest Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
- Shanghai First People's Hospital (CN)
- Community Health Center (US)
Publication Details
- Journal
- Biomedical Journal
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1016/j.bj.2025.100870
- Citations
- 3
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.16
Funders
- National Natural Science Foundation of China