Young adults with type 2 diabetes experience high rates of Level 3 Hypoglycemia: A subgroup analysis of the Real-World iNPHORM cohort
Young adults exhibited a threefold higher incidence of Level 3 hypoglycemia events requiring medical assistance compared to the middle-aged cohort at baseline (p < 0.001). During follow-up, the young adults experienced a twofold higher incidence proportion of Level 3 hypoglycemia (p < 0.001), and n a fivefold higher annualized rate (p < 0.001); they also reported greater hypoglycemia fear (p < 0.001). Distinct sociodemographics, general health and lifestyle factors, diabetes medical history, and diabetes therapy and technology use characteristics were observed in the young-adult group, as were unique risk factors for Level 3 hypoglycemia frequency CONCLUSION: Our results suggest that young adults with T2D are at particularly high risk of Level 3 hypoglycemia, with attributes that differ from those of the traditional middle-aged cohort.
Authors
- Bridget Ryan (ORCID: https://orcid.org/0000-0001-9080-5635)
- Alexandria Ratzki‐Leewing (ORCID: https://orcid.org/0000-0002-9474-7900)
- Jason Black (ORCID: https://orcid.org/0000-0002-3762-3231)
- Yu Kuei Lin (ORCID: https://orcid.org/0000-0003-1988-7046)
- Stewart B. Harris (ORCID: https://orcid.org/0000-0002-1794-6551)
- Guangyong Zou (ORCID: https://orcid.org/0000-0001-5773-4185)
Institutions
- Western University (CA)
- University of Maryland, Baltimore (US)
- Robarts Clinical Trials (CA)
- Michigan Medicine (US)
Publication Details
- Journal
- Diabetes Research and Clinical Practice
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1016/j.diabres.2025.112230
- Citations
- 1
- Primary Topic
- Diabetes Management and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.29