Young adults with type 2 diabetes experience high rates of Level 3 Hypoglycemia: A subgroup analysis of the Real-World iNPHORM cohort

Young adults exhibited a threefold higher incidence of Level 3 hypoglycemia events requiring medical assistance compared to the middle-aged cohort at baseline (p < 0.001). During follow-up, the young adults experienced a twofold higher incidence proportion of Level 3 hypoglycemia (p < 0.001), and n a fivefold higher annualized rate (p < 0.001); they also reported greater hypoglycemia fear (p < 0.001). Distinct sociodemographics, general health and lifestyle factors, diabetes medical history, and diabetes therapy and technology use characteristics were observed in the young-adult group, as were unique risk factors for Level 3 hypoglycemia frequency CONCLUSION: Our results suggest that young adults with T2D are at particularly high risk of Level 3 hypoglycemia, with attributes that differ from those of the traditional middle-aged cohort.

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Publication Details

Journal
Diabetes Research and Clinical Practice
Published
2025-05-06
DOI
https://doi.org/10.1016/j.diabres.2025.112230
Citations
1
Primary Topic
Diabetes Management and Research
Type
article
Field-Weighted Citation Impact
1.29
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article

Young adults with type 2 diabetes experience high rates of Level 3 Hypoglycemia: A subgroup analysis of the Real-World iNPHORM cohort

Bridget Ryan, Alexandria Ratzki‐Leewing, Jason Black, Yu Kuei Lin et al.
1 citations
Diabetes Research and Clinical Practice
Diabetes Management and Research
1.29
article

Young adults with type 2 diabetes experience high rates of Level 3 Hypoglycemia: A subgroup analysis of the Real-World iNPHORM cohort

Bridget Ryan, Alexandria Ratzki‐Leewing, Jason Black, Yu Kuei Lin, Stewart B. Harris, Guangyong Zou
article en
1 citations

Abstract

Young adults exhibited a threefold higher incidence of Level 3 hypoglycemia events requiring medical assistance compared to the middle-aged cohort at baseline (p < 0.001). During follow-up, the young adults experienced a twofold higher incidence proportion of Level 3 hypoglycemia (p < 0.001), and n a fivefold higher annualized rate (p < 0.001); they also reported greater hypoglycemia fear (p < 0.001). Distinct sociodemographics, general health and lifestyle factors, diabetes medical history, and diabetes therapy and technology use characteristics were observed in the young-adult group, as were unique risk factors for Level 3 hypoglycemia frequency CONCLUSION: Our results suggest that young adults with T2D are at particularly high risk of Level 3 hypoglycemia, with attributes that differ from those of the traditional middle-aged cohort.

Diabetes Research and Clinical PracticeVol. 225
Western University (CA), University of Maryland, Baltimore (US), Robarts Clinical Trials (CA), Michigan Medicine (US)
Openalex Percentile: Top 20%
Diabetes Management and Research
1.29
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Young adults with type 2 diabetes experience high rates of Level 3 Hypoglycemia: A subgroup analysis of the Real-World iNPHORM cohort — Bridget Ryan, Alexandria Ratzki‐Leewing, et al. · Diabetes Research and Clinical Practice (2025) | TGRS Research Map | TGRS