Genomic insights into the population history of fat-tailed sheep and identification of two mutations that contribute to fat tail adipogenesis
Our study provides the first evidence that these genes jointly regulate fat tail development through complementary mechanisms: PDGFD promotes adipose expansion, whereas BMP2 modulates energy partitioning. These findings offer new insights into the evolutionary history of fat-tailed sheep and identify potential targets for precision breeding in small ruminants.
Authors
- Hai Jin (ORCID: https://orcid.org/0009-0008-2296-7331)
- Enmin Liu
- Xiaojuan Fei
- Zengkui Lu (ORCID: https://orcid.org/0000-0002-5993-1083)
- Zehu Yuan (ORCID: https://orcid.org/0000-0002-6150-0258)
- Huihua Wang (ORCID: https://orcid.org/0009-0006-3457-7459)
- Xunping Jiang (ORCID: https://orcid.org/0000-0001-7822-1784)
- Yongbin Liu (ORCID: https://orcid.org/0000-0001-8358-7342)
- Yu Jiang (ORCID: https://orcid.org/0000-0003-4821-3585)
- Kai Quan (ORCID: https://orcid.org/0000-0002-0015-8663)
- Meilin Jin (ORCID: https://orcid.org/0000-0001-5528-4336)
- Caihong Wei (ORCID: https://orcid.org/0000-0001-9185-0251)
- Jiaxue Cao (ORCID: https://orcid.org/0000-0001-9953-9898)
- Gang Liu (ORCID: https://orcid.org/0000-0001-6313-7758)
- Jian Lu (ORCID: https://orcid.org/0000-0003-0760-0247)
- Taotao Li (ORCID: https://orcid.org/0000-0002-8400-9824)
- Lizhong Wang (ORCID: https://orcid.org/0000-0002-3571-8771)
- Lixin Du (ORCID: https://orcid.org/0000-0002-3287-5018)
- Youji Ma (ORCID: https://orcid.org/0000-0002-4328-5654)
- Zhuqing Zheng (ORCID: https://orcid.org/0000-0002-4570-7646)
Institutions
- BGI Group (China) (CN)
- Gansu Agricultural University (CN)
- Henan University (CN)
- Huazhong Agricultural University (CN)
- Lanzhou Institute of Husbandry and Pharmaceutical Sciences (CN)
- Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences (CN)
- National Animal Husbandry Service (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Institute of Animal Sciences (CN)
- Yangzhou University (CN)
- Northwest A&F University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1016/j.jare.2025.05.011
- Citations
- 5
- Primary Topic
- Genetic and phenotypic traits in livestock
- Type
- article
- Field-Weighted Citation Impact
- 9.09
Funders
- National Natural Science Foundation of China
- Agriculture Research System of China
- Ministry of Agriculture and Rural Affairs of the People's Republic of China