Ultrasound-Assisted Synthesis of Mangosteen Nanoparticles: Characterization of Particle Size, Phytochemical Content, Antibacterial, and Antioxidant Properties

Diabetic foot wounds present a significant challenge in clinical management, necessitating innovative wound care approaches. This study evaluated the effectiveness of Garcinia mangostana Linn nanoparticle spray in promoting wound healing in diabetic foot wounds, focusing on wound size, TNF-? levels, and fibroblast activity. Using an experimental design with a diabetic animal model, the study assessed the impact of Garcinia mangostana Linn nanoparticle spray on these key parameters. Statistical analysis revealed a significant reduction in wound size (p=0.013), a notable decrease in TNF-? levels (p=0.001), and a strong fibroblast response (p=0.000), indicating enhanced collagen production and tissue formation. These findings suggest that Garcinia mangostana Linn nanoparticle spray has promising therapeutic potential in diabetic wound care by reducing inflammation and accelerating tissue regeneration.