Heart Failure and Obesity: Translational Approaches and Therapeutic Perspectives. A Scientific Statement of the Heart Failure Association of the ESC
Obesity and heart failure (HF) represent two growing pandemics. In the general population, obesity affects one in eight adults and is linked with an increased risk for HF. Obesity is even more common in patients with HF, where it complicates the diagnosis of HF and is linked with worse symptoms and impaired exercise capacity. Over the past few years, new evidence on the mechanisms linking obesity with HF has been reported, particularly in relation to HF with preserved ejection fraction. Novel therapies inducing weight loss appear to have favourable effects on health status and cardiovascular risk. Against the backdrop of this rapidly evolving evidence landscape, HF clinicians are increasingly required to tailor their preventive, diagnostic, and therapeutic approaches to HF in the presence of obesity. This scientific statement by the Heart Failure Association of the European Society of Cardiology provides an up-to-date summary on obesity in HF, covering key areas such as epidemiology, translational aspects, diagnostic challenges, therapeutic approaches, and trial design.
Authors
- Markus S. Anker (ORCID: https://orcid.org/0000-0002-4406-8555)
- Arantxa González (ORCID: https://orcid.org/0000-0001-5986-6528)
- Nicolas Girerd (ORCID: https://orcid.org/0000-0002-3278-2057)
- Mark C. Petrie (ORCID: https://orcid.org/0000-0002-6333-9496)
- Gianluigi Savarese (ORCID: https://orcid.org/0000-0001-7732-0887)
- Antoni Bayés‐Genís (ORCID: https://orcid.org/0000-0002-3044-197X)
- Emilia D’Elia (ORCID: https://orcid.org/0000-0002-6682-0074)
- Christoph Maack (ORCID: https://orcid.org/0000-0003-3694-4559)
- Antonio Nicola Cannata (ORCID: https://orcid.org/0000-0001-7609-6297)
- Gabriele G. Schiattarella (ORCID: https://orcid.org/0000-0002-7582-7171)
- Magnus Bäck (ORCID: https://orcid.org/0000-0003-0853-5141)
- Carlo G. Tocchetti (ORCID: https://orcid.org/0000-0001-5983-688X)
- Ovidiu Chioncel (ORCID: https://orcid.org/0000-0002-3197-3628)
- Federico Capone (ORCID: https://orcid.org/0000-0001-8127-5564)
- Frieder Braunschweig (ORCID: https://orcid.org/0000-0002-4966-1315)
- Carolyn S.P. Lam (ORCID: https://orcid.org/0000-0003-1903-0018)
- Lars H. Lund (ORCID: https://orcid.org/0000-0003-1411-4482)
- Giuseppe Rosano (ORCID: https://orcid.org/0000-0002-6868-4248)
- Felix Lindberg (ORCID: https://orcid.org/0000-0002-7380-9877)
- Peter Seferović
- Jean‐Sébastien Hulot (ORCID: https://orcid.org/0000-0001-5463-6117)
- Javed Butler (ORCID: https://orcid.org/0000-0003-4267-6933)
- Massimo Piepoli (ORCID: https://orcid.org/0000-0003-1124-234X)
- Chiara Bucciarelli‐Ducci (ORCID: https://orcid.org/0000-0002-2515-0852)
- Mehmet Birhan Yılmaz (ORCID: https://orcid.org/0000-0002-8169-8628)
- Brenda Moura
- Abdullah Shehab
- Marco Metra
Institutions
- Serbian Academy of Sciences and Arts (RS)
- University of Padua (IT)
- Inserm (FR)
- Carol Davila University of Medicine and Pharmacy (RO)
- National University of Singapore (SG)
- Universidade do Porto (PT)
- King's College London (GB)
- Università degli studi di Cassino e del Lazio Meridionale (IT)
- Dokuz Eylül University (TR)
- National and Kapodistrian University of Athens (GR)
- Université Paris Cité (FR)
- Max Delbrück Center (DE)
- University of Wrocław (PL)
- University of Würzburg (DE)
- Instituto de Salud Carlos III (ES)
- Harefield Hospital (GB)
- Karolinska Institutet (SE)
- San Raffaele University of Rome (IT)
- Brescia University (US)
- British Heart Foundation (GB)
- University of Mississippi (US)
- Wroclaw Medical University (PL)
- University of Belgrade (RS)
- Al Ain Hospital (AE)
- Stockholm South General Hospital (SE)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Assistance Publique – Hôpitaux de Paris (FR)
- IRCCS Policlinico San Donato (IT)
- Comprehensive Cancer Center Mainfranken (DE)
- Hôpital Européen Georges-Pompidou (FR)
- Surgical Specialties (Canada) (CA)
- Deutsches Herzzentrum der Charité (DE)
- Ospedale Papa Giovanni XXIII (IT)
- National University Heart Centre Singapore (SG)
- Hôpital Européen (FR)
- Baylor Medical Center at Garland (US)
- King's College Hospital NHS Foundation Trust (GB)
- CUF Porto Hospital (PT)
- Armed Forces Hospital (SA)
- Federico II University Hospital (IT)
- King's College School (GB)
- St. Thomas Hospital (CA)
- Universitätsklinikum Würzburg (DE)
- German Centre for Cardiovascular Research (DE)
- Paris Cardiovascular Research Center (FR)
- Clinica Universidad de Navarra (ES)
- University of Arts in Belgrade (RS)
- National Heart Centre Singapore (SG)
- Hospital Universitari Germans Trias i Pujol (ES)
- Berlin Heart (Germany) (DE)
- French Clinical Research Infrastructure Network (FR)
- University of Milano-Bicocca (IT)
- Charité - Universitätsmedizin Berlin (DE)
- University of Glasgow (GB)
- University of Brescia (IT)
- Universidad de Navarra (ES)
- Université de Lorraine (FR)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1002/ejhf.3676
- Citations
- 21
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 29.15