Immune cells mediate the effect of plasma lipidomes on IgA nephropathy: a Mendelian randomization study
Our findings provide robust genetic evidence supporting a causal link between plasma lipidomes and IgAN, with immune cells acting as potential mediators. Phosphatidylinositol (18:1_20:4) emerges as a promising biomarker for IgAN risk stratification, early detection, and therapeutic intervention. Modulating its plasma levels may offer novel avenues for IgAN management.
Authors
- Y. Eugene Chen (ORCID: https://orcid.org/0000-0003-2357-7825)
- Junjie Pan (ORCID: https://orcid.org/0000-0002-7570-6927)
- Quanxin Li (ORCID: https://orcid.org/0000-0002-1457-5345)
- Xiaolin Liu (ORCID: https://orcid.org/0000-0002-0664-6027)
- Li Xiao (ORCID: https://orcid.org/0000-0002-5488-5583)
- Yueqin Zhu (ORCID: https://orcid.org/0009-0009-4090-1624)
- Xiaoyang Cui (ORCID: https://orcid.org/0000-0001-5203-0728)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Zhengzhou University (CN)
- Second Hospital of Shandong University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Renal Failure
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1080/0886022x.2025.2498631
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Shandong Province