Relationship between time-varying achieved HbA<sub>1c</sub> and risk of coronary artery disease events among common haptoglobin phenotype groups with type 2 diabetes: the ADVANCE study
The present ADVANCE analysis suggests that not having HbA<sub>1c</sub> ≥8.0%, rather than achieving HbA<sub>1c</sub> <7.0%, was found to be particularly important for CAD prevention among people with type 2 diabetes and the common Hp2-2 phenotype. While the subgroup analyses were likely underpowered, their inclusion is hypothesis generating and can be used in future meta-analyses to improve power and generalizability.
Authors
- Elizabeth Selvin (ORCID: https://orcid.org/0000-0001-6923-7151)
- Mark Woodward (ORCID: https://orcid.org/0000-0001-9800-5296)
- Stephen Harrap (ORCID: https://orcid.org/0000-0003-2907-6714)
- Katie Harris (ORCID: https://orcid.org/0000-0003-2444-2869)
- Eric B. Rimm (ORCID: https://orcid.org/0000-0002-1402-7250)
- John Chalmers (ORCID: https://orcid.org/0000-0002-9931-0580)
- Michelle Samuel (ORCID: https://orcid.org/0000-0002-9674-6565)
- Leah E. Cahill (ORCID: https://orcid.org/0000-0003-3584-2227)
- Rachel A Warren
- Neil R Poulter (ORCID: https://orcid.org/0000-0002-6292-997X)
- John L. Sapp (ORCID: https://orcid.org/0000-0002-9602-2751)
- Andrew P. Levy (ORCID: https://orcid.org/0000-0003-0195-5178)
- Giuseppe Mancia (ORCID: https://orcid.org/0000-0003-0942-3176)
- Michel Marre (ORCID: https://orcid.org/0000-0002-3071-1837)
- Allie S. Carew
- Samantha K Lavallée
Institutions
- Dalhousie University (CA)
- University Medical Center Groningen (NL)
- Harvard University (US)
- Johns Hopkins University (US)
- The University of Melbourne (AU)
- University of Groningen (NL)
- Technion – Israel Institute of Technology (IL)
- The George Institute for Global Health (GB)
- Université Paris Cité (FR)
- London International Development Centre (GB)
- Nova Scotia Health Authority (CA)
- The George Institute for Global Health (AU)
- Clinique Ambroise Paré (FR)
- Imperial College London (GB)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- BMJ Open Diabetes Research & Care
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1136/bmjdrc-2024-004713
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Research Nova Scotia
- National Institutes of Health
- Canadian Institutes of Health Research
- Medical Research Council
- National Health and Medical Research Council
- National Heart, Lung, and Blood Institute