Forskolin treatment enhances muscle regeneration and shows therapeutic potential with limitations in Duchenne muscular dystrophy
FSK shows promising results in improving muscle regeneration and reducing fibrosis in DMD, but concerns remain regarding its limited chronic functional benefits and potential adverse effects on cardiac tissue. Our results highlight the need for optimized adenylyl cyclase activators for therapeutic use in DMD patients.
Authors
- Jean-Daniel Masson (ORCID: https://orcid.org/0000-0001-6861-9967)
- Laurent Tiret (ORCID: https://orcid.org/0000-0001-8573-8335)
- Valentina Taglietti (ORCID: https://orcid.org/0000-0001-8639-8088)
- Kaouthar Kefi
- Frédéric Relaix (ORCID: https://orcid.org/0000-0003-1270-1472)
- Andreea Iuliana Cojocaru
Institutions
- Inserm (FR)
- Université Paris-Est Créteil (FR)
- Institut Mondor de Recherche Biomédicale (FR)
Publication Details
- Journal
- Skeletal Muscle
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1186/s13395-025-00381-7
- Citations
- 2
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Agence Nationale de la Recherche
- AFM-Téléthon
- H2020 Marie Skłodowska-Curie Actions