Uncovering potential biomarkers and metabolic pathways in systemic lupus erythematosus and lupus nephritis through integrated microbiome and metabolome analysis
This integrative analysis suggests that patients with SLE and LN harbor distinct gut microbiota and metabolomic profiles. The identified microbial taxa and metabolites may have potential as non-invasive biomarkers and could contribute to a better understanding of SLE pathogenesis and progression.
Authors
- Han Shen (ORCID: https://orcid.org/0000-0003-0366-4403)
- Xiaojie Chu (ORCID: https://orcid.org/0000-0002-2745-004X)
- Adeel Khan (ORCID: https://orcid.org/0000-0001-8766-0551)
- Siyun Cheng
- Zhongyu Wang (ORCID: https://orcid.org/0009-0008-8343-7035)
- Yue Tao (ORCID: https://orcid.org/0000-0003-1767-4290)
- Ping Yang (ORCID: https://orcid.org/0000-0002-0321-1132)
Institutions
- Xuzhou Medical College (CN)
- Nanjing Drum Tower Hospital (CN)
- University of Science and Technology Bannu (PK)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s12866-025-03995-5
- Citations
- 6
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 10.01
Funders
- National Natural Science Foundation of China
- Nanjing Drum Tower Hospital
- Nanjing Medical Science and Technique Development Foundation