Evaluation of lung epithelial lining fluid concentrations of lascufloxacin against Streptococcus pneumoniae in a hollow-fiber infection model
Lascufloxacin (LSFX) achieves concentrations in epithelial lining fluid (ELF) that are more than 15 times higher than those in the bloodstream, making it a promising candidate for respiratory and otorhinolaryngological infections. These concentrations were replicated using the Hollow-Fiber Infection Model and demonstrated bactericidal efficacy of LSFX against levofloxacin-sensitive and -resistant Streptococcus pneumoniae. The study confirms that LSFX's elevated concentration in ELF plays a significant role in its bactericidal activity.
Authors
- Kazuaki Matsumoto (ORCID: https://orcid.org/0000-0002-5462-1684)
- Masakaze Hamada (ORCID: https://orcid.org/0000-0002-0482-8986)
- Ryo Miyake (ORCID: https://orcid.org/0000-0002-9170-0402)
- Toshihiro Kasama (ORCID: https://orcid.org/0000-0001-6753-1509)
- Haruka Nakagawa Kamura
- Tetsuo Yamaguchi (ORCID: https://orcid.org/0000-0002-6220-1890)
- Yoshikazu Ishii
- Yukitaka Hayashi
Institutions
- Toho University (JP)
- Keio University (JP)
- Planetary Systems (United States) (US)
- The University of Tokyo (JP)
Publication Details
- Journal
- The Journal of Antibiotics
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1038/s41429-025-00826-7
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development