A Common Medication With a Rare Side Effect: A Case Report of Statin-Induced Necrotizing Autoimmune Myopathy

Statins are commonly used for their cholesterol-lowering properties and are prescribed for primary and secondary prevention of cardiovascular disease. Although they are generally well tolerated, some individuals may experience a rare and serious side effect in which autoantibodies develop and lead to a necrotizing myopathy. Here we present a case of a middle-aged woman chronically on atorvastatin for her hyperlipidemia who acutely developed myalgias, muscle weakness, and persistently elevated creatine kinase, who was eventually diagnosed with statin-induced necrotizing autoimmune myopathy.

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Publication Details

Journal
Cureus
Published
2025-05-06
DOI
https://doi.org/10.7759/cureus.83589
Primary Topic
Inflammatory Myopathies and Dermatomyositis
Type
article
Field-Weighted Citation Impact
0.00
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article

A Common Medication With a Rare Side Effect: A Case Report of Statin-Induced Necrotizing Autoimmune Myopathy

Meghan Grossmann, Michelle Jin, Eric Scher, Madison Drallmeier
Cureus
Inflammatory Myopathies and Dermatomyositis
article

A Common Medication With a Rare Side Effect: A Case Report of Statin-Induced Necrotizing Autoimmune Myopathy

Meghan Grossmann, Michelle Jin, Eric Scher, Madison Drallmeier
article en

Abstract

Statins are commonly used for their cholesterol-lowering properties and are prescribed for primary and secondary prevention of cardiovascular disease. Although they are generally well tolerated, some individuals may experience a rare and serious side effect in which autoantibodies develop and lead to a necrotizing myopathy. Here we present a case of a middle-aged woman chronically on atorvastatin for her hyperlipidemia who acutely developed myalgias, muscle weakness, and persistently elevated creatine kinase, who was eventually diagnosed with statin-induced necrotizing autoimmune myopathy.

CureusVol. 17(5)
Henry Ford Health System (US), Detroit Medical Center (US)
Good health and well-being
Openalex Percentile: Top 86%
Inflammatory Myopathies and Dermatomyositis
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