STUDY OF THE ANTIFUNGAL ACTION OF ETHYL S-ESTER OF 4-ACETYLAMINOBENZENETHIOSULFICAL ACID

For the treatment of fungal skin diseases of animals, systemic and local antifungal agents are used, which are able to inhibit the growth of microscopic fungi. With the spread of fungal skin diseases and the formation of resistance to antifungal agents, the question arises of developing alternative drugs that would meet modern requirements. In this aspect, an important place belongs to S-esters of thiosulfonic acids, which are structural analogues of the sulfur-containing organic compound - allicin. The article presents the results of studying the antifungal effect of the ethyl S-ester of 4-acetylaminobenzenethiosulfonic acid. It was established that the activity of the ethyl S-ester of 4-acetylaminobenzenethiosulfonic acid against museum and clinical test strains of yeast-like fungi Candida albicans ATCC 10231, Saccharomyces cerevisiae, and mold fungi Aspergillus brasiliensis YKM F-16693 and Mucor racemosus at a pH of 7,0 units was at a concentration of 250 μg/cm³. With a change in the pH of the medium to a slightly acidic side to an indicator of 5,2 units, the activity of the studied substance increased, compared to a pH of the medium of 7,0 units, and was 125 μg/cm³ against Candida albicans ATCC 10231 and Saccharomyces cerevisiae, and 62,5 μg/cm3 against Aspergillus brasiliensis YKM F-16693 and Mucor racemosus. At a pH of 8,8 units, the activity of the studied substance decreased compared to pH values of 7,0 and 5,2 units. The dependence of the sensitivity of yeast-like fungi and mold fungi on the pH of the medium was also established. With a decrease in the pH of the medium to 5,2 units, the sensitivity of yeast-like fungi and mold fungi increased. In particular, the sensitivity of Candida albicans ATCC 10231 and Saccharomyces cerevisiae increased by 8,2 (p<0,05) and 2,9%, respectively, compared to a pH of the medium of 7,0. As for mold fungi, the sensitivity of Aspergillus brasiliensis YKM F-16693 and Mucor racemosus to ethyl S-ester of 4-acetylaminobenzenethiosulfonic acid increased by 7,3 (p<0,01) and 5,9 % (p<0.05), respectively. At a pH of the medium of 8,8 units, the sensitivity of microscopic fungi decreased compared to a pH of the medium of 7,0 and 5,2 units.