Biomarkers of response to antibody-drug conjugates (TROP2 and nectin-4) and the immune microenvironment (NKG7, PD-L1, and B7-H3) in penile squamous cell carcinoma
Therapeutic strategies targeting TROP2 and nectin-4 hold promise for patients with advanced pSCC. The potential of PD-L1, B7-H3, and NKG7 for predicting response to immunomodulatory treatment warrants further research.
Authors
- Carin Y. Smith (ORCID: https://orcid.org/0000-0002-3610-6945)
- Ruifeng Guo (ORCID: https://orcid.org/0009-0000-9075-1884)
- Karla Kopp
- Sarah M. Jenkins (ORCID: https://orcid.org/0000-0002-4157-8066)
- Lori Erickson (ORCID: https://orcid.org/0000-0003-0406-6595)
- Haidong Dong (ORCID: https://orcid.org/0000-0002-5782-2983)
- Brandy L. Jaszewski
- Sounak Gupta (ORCID: https://orcid.org/0000-0001-5163-6955)
- Roxane R. Lavoie (ORCID: https://orcid.org/0000-0001-6253-8090)
- Rumeal D. Whaley (ORCID: https://orcid.org/0000-0001-9256-4484)
- Surendra Dasari (ORCID: https://orcid.org/0000-0002-7972-3556)
- Burak Tekin (ORCID: https://orcid.org/0000-0002-2330-1215)
- Stephen A. Boorjian (ORCID: https://orcid.org/0000-0002-8705-6650)
- Lance C. Pagliaro (ORCID: https://orcid.org/0000-0002-4209-3394)
- John C. Cheville (ORCID: https://orcid.org/0000-0002-8202-6268)
- Ava Farrell
- Fabrice Lucien (ORCID: https://orcid.org/0000-0001-6149-345X)
- Michael J. McCarthy (ORCID: https://orcid.org/0000-0001-6219-4945)
- Santosh Menon
- Nate R Torell
Institutions
- Homi Bhabha National Institute (IN)
- Tata Memorial Hospital (IN)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- American Journal of Clinical Pathology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1093/ajcp/aqaf022
- Citations
- 5
- Primary Topic
- Genital Health and Disease
- Type
- article
- Field-Weighted Citation Impact
- 10.03