A Ruthenium(II)‐DNA Nanophotosensitizer for cGAS‐STING‐Mediated Photodynamic Immunotherapy Against Hypoxic Cisplatin‐Resistant Tumor Cells
Plasmid DNAs intercalated with Ru(II) complexes were encapsulated in liposomes to create nano-photosensitizers. Upon light exposure, the ruthenium complex photo-cleavages DNA. The DNA fragments specifically stimulate the cGAS-STING pathway and induce immunogenic death. This study presents a convenient strategy for photodynamic immunotherapy against cisplatin-resistant tumor cells under hypoxia.
Authors
- Hui Chao (ORCID: https://orcid.org/0000-0003-4153-5303)
- Yu Chen (ORCID: https://orcid.org/0000-0001-5219-9195)
- Fa Wang (ORCID: https://orcid.org/0000-0002-0456-5207)
- Zhiyang Wang
- Jinrong Yang (ORCID: https://orcid.org/0000-0002-7678-0360)
- Shuqi Huang (ORCID: https://orcid.org/0009-0008-7557-4822)
Institutions
- Hunan University of Science and Technology (CN)
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1002/chem.202501016
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China