A promising approach to diabetic osteoporosis: oxymatrine’s effects on gut microbiota and osteoblasts
OMT improves diabetic osteoporosis by altering gut microbiota, decreasing LPS release, and enhancing osteoblast growth and differentiation through the miR-539-5p/OGN/Runx2 pathway, suggesting its potential as a treatment.
Authors
- Peijian Tong (ORCID: https://orcid.org/0009-0003-3544-8913)
- Dan Shou (ORCID: https://orcid.org/0000-0003-3465-4072)
- Yang Zhang (ORCID: https://orcid.org/0000-0002-2739-1916)
- Minjie Zhang
- Mengying Li (ORCID: https://orcid.org/0000-0002-3713-1683)
- Yiwen Zhu (ORCID: https://orcid.org/0009-0005-1410-3662)
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Nutrition and Diabetes
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1038/s41387-025-00374-x
- Citations
- 5
- Primary Topic
- Natural Antidiabetic Agents Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.47
Funders
- National Natural Science Foundation of China
- Zhejiang Chinese Medical University
- Zhejiang Traditional Chinese Medicine Administration