Matrix metalloproteinase (MMP)-10 aggravates podocyte injury in glomerulonephritis
These findings suggest that GC-A ablation leads to upregulation of MMP-10, resulting in nephrin loss, and that systemic deletion of MMP-10 ameliorates GC-A-induced podocyte injury.
Authors
- Takuya Ishimura
- Keisuke Osaki
- Takeshi Tokudome (ORCID: https://orcid.org/0000-0002-9117-3550)
- Taiji Matsusaka (ORCID: https://orcid.org/0000-0001-9466-4585)
- Hiroyuki Yamada (ORCID: https://orcid.org/0000-0002-5167-3147)
- Naohiro Toda (ORCID: https://orcid.org/0000-0002-8475-5827)
- Shoko Ohno
- Motoko Yanagita (ORCID: https://orcid.org/0000-0002-0339-9008)
- Sayaka Sugioka
- Akira Ishii (ORCID: https://orcid.org/0000-0003-4234-2749)
- Hideki Yokoi (ORCID: https://orcid.org/0000-0001-8343-9737)
- Yukiko Kato
Institutions
- Tokai University (JP)
- Kyoto University (JP)
- Kansai Electric Power Hospital (JP)
- Kobe City Medical Center General Hospital (JP)
- Yokohama City University (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1093/ndt/gfaf076
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00