Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice
This work was supported by the National Institutes of Health (NIH), Veteran Affairs (VA), Breakthrough T1D, and gifts from the Sigma Beta Sorority, the Ball Brothers Foundation, and the George and Frances Ball Foundation.
Authors
- Piero Marchetti (ORCID: https://orcid.org/0000-0003-4907-0635)
- Jamie L. Felton (ORCID: https://orcid.org/0000-0002-6170-1156)
- Stéphane Demine (ORCID: https://orcid.org/0000-0002-7254-2269)
- Eugenia Martin Vázquez
- Preethi Krishnan (ORCID: https://orcid.org/0000-0002-3786-5732)
- Kara S. Orr (ORCID: https://orcid.org/0000-0002-1321-8581)
- Maria Inês Alvelos (ORCID: https://orcid.org/0000-0003-2897-5646)
- Ângela Castela
- Alexandra Coomans de Brachène (ORCID: https://orcid.org/0000-0002-4361-5078)
- Farooq Syed (ORCID: https://orcid.org/0000-0002-0284-0631)
- Arnaud Zaldumbide (ORCID: https://orcid.org/0000-0001-6680-4456)
- Lorella Marselli (ORCID: https://orcid.org/0000-0002-6698-2962)
- Staci A. Weaver (ORCID: https://orcid.org/0000-0002-2974-2580)
- Carmella Evans‐Molina (ORCID: https://orcid.org/0000-0001-7764-8663)
- Décio L. Eizirik (ORCID: https://orcid.org/0000-0003-2453-5889)
- Sofia Thomaidou (ORCID: https://orcid.org/0000-0003-1624-2138)
- Donalyn Scheuner
- John S. Kaddis (ORCID: https://orcid.org/0000-0002-6752-7670)
- Jing Liu (ORCID: https://orcid.org/0000-0002-0493-296X)
- Garrick Chang (ORCID: https://orcid.org/0009-0007-0741-7588)
- Jyoti Rana (ORCID: https://orcid.org/0000-0001-9683-4592)
- Olivia Ballew
- Namratha Shivani Chalasani
- Chih‐Chun Lee (ORCID: https://orcid.org/0000-0003-2802-519X)
Institutions
- University of Pisa (IT)
- Université Libre de Bruxelles (BE)
- Purdue University West Lafayette (US)
- Leiden University Medical Center (NL)
- Indiana Biosciences Research Institute (US)
- Richard L. Roudebush VA Medical Center (US)
- City of Hope (US)
- Indiana University Indianapolis (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- EBioMedicine
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1016/j.ebiom.2025.105734
- Citations
- 8
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 16.05
Funders
- Ball Brothers Foundation
- Bristol-Myers Squibb
- George and Frances Ball Foundation
- European Commission
- National Institutes of Health
- School of Medicine, Indiana University
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Advancing Translational Sciences