Mechanisms of Acetate in Alleviating SETDB1-Linked Neuroinflammation and Cognitive Impairment in a Mouse Model of OSA
This study provides the first evidence that H3K9 methyltransferase SETDB1 promotes microglial pro-inflammatory response distinct from its previously shown role in macrophages. Our findings also identify ACE supplementation as a promising dietary intervention for OSA-related cognitive impairment with SETDB1 serving as both a mechanistic biomarker and potential therapeutic target.
Authors
- Zhengqing Zhao (ORCID: https://orcid.org/0000-0002-1668-7092)
- Jau‐Shyong Hong (ORCID: https://orcid.org/0000-0002-3056-8401)
- Yubao Wang (ORCID: https://orcid.org/0000-0003-0332-7984)
- Li Xiang
- Jing Feng (ORCID: https://orcid.org/0000-0003-0604-3581)
Institutions
- National Institutes of Health (US)
- Tianjin Medical University General Hospital (CN)
- National Institute of Environmental Health Sciences (US)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/jir.s510690
- Citations
- 2
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 2.24