Structural analysis of a micron-sized deposit of Cu0 in an insulin ball from a person with diabetes
The largest amount of Cu<sup>0</sup> found in living things is in a human. Our discovery of 100 µm Cu<sup>0</sup> within the insulin ball supports the idea that insulin preparations from outside can disrupt the balance of metals, including Cu. In 2025, the patient continues to inject subcutaneous insulin preparations, but no new insulin balls appear.
Authors
- Haruhiko Sugimura (ORCID: https://orcid.org/0000-0002-0779-3088)
- Nobumasa Nagami (ORCID: https://orcid.org/0000-0002-5976-2267)
- Yoshiyuki Itoh (ORCID: https://orcid.org/0000-0003-1905-1783)
- Tamotsu Zako (ORCID: https://orcid.org/0000-0001-7106-5766)
- Terumasa Nagase (ORCID: https://orcid.org/0000-0003-2956-0071)
- Hisae Arai
- Keiichi Iwaya (ORCID: https://orcid.org/0000-0003-1839-1209)
- Takashi Ishikawa (ORCID: https://orcid.org/0000-0003-3450-4533)
- Takashima Yoshiko
Institutions
- JEOL (Japan) (JP)
- Tokyo Medical University (JP)
- Sasaki Institute (JP)
- Hyogo Prefectural Police (JP)
- Noritake (Japan) (JP)
- R2M Solution (Italy) (IT)
- Tokyo Medical University Ibaraki Medical Center (JP)
- Ehime University (JP)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1038/s43856-025-00889-5
- Citations
- 1
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 1.12
Funders
- Japan Society for the Promotion of Science