Roles of macrophages and monocytes in resistance to immunotherapy in breast cancers

A multimodal strategy targeting macrophages, monocytes, and complementary immunotherapies offers promising avenues to overcome resistance. Further research into the heterogeneity and regulatory mechanisms of these cells is critical for developing optimized, safe immunotherapeutic protocols. This review underscores the necessity of combination immunotherapies to improve outcomes in breast cancer.

Authors

Lihong Hu (ORCID: https://orcid.org/0000-0003-3231-2829)
Chengdong Qin
Siyuan Liu (ORCID: https://orcid.org/0000-0003-1051-960X)
Chuner Jiang
Jiejie Hu (ORCID: https://orcid.org/0000-0003-2110-9665)
Yu Yang (ORCID: https://orcid.org/0000-0002-9213-9979)

Institutions

Wenzhou Medical University (CN)
Zhejiang Cancer Hospital (CN)

Publication Details

Journal: Postgraduate Medical Journal
Published: 2025-05-05
DOI: https://doi.org/10.1093/postmj/qgaf065
Citations: 3
Primary Topic: Immune cells in cancer
Type: article
Field-Weighted Citation Impact: 2.39

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article

Roles of macrophages and monocytes in resistance to immunotherapy in breast cancers

Lihong Hu, Chengdong Qin, Siyuan Liu, Chuner Jiang et al.

May 5, 2025

3 citations

Postgraduate Medical Journal

Immune cells in cancer

2.39

article

Roles of macrophages and monocytes in resistance to immunotherapy in breast cancers

Lihong Hu, Chengdong Qin, Siyuan Liu, Chuner Jiang, Jiejie Hu, Yu Yang

May 5, 2025article en

3 citations

Abstract

A multimodal strategy targeting macrophages, monocytes, and complementary immunotherapies offers promising avenues to overcome resistance. Further research into the heterogeneity and regulatory mechanisms of these cells is critical for developing optimized, safe immunotherapeutic protocols. This review underscores the necessity of combination immunotherapies to improve outcomes in breast cancer.

Postgraduate Medical JournalVol. 101(1202)

Wenzhou Medical University (CN), Zhejiang Cancer Hospital (CN)

Good health and well-being

Openalex Percentile: Top 12%

Immune cells in cancer

2.39

DOI Source OpenAlex

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