Intentional Nitrite Ingestion: Clinical Presentation and Emergency Management in a Young Female Patient

Sodium nitrite (NaNO₂) is an inorganic salt used in food preservation and industrial products, recently implicated in self-harm due to its easy online availability. We report a case of severe methemoglobinemia in a 20-year-old woman following sodium nitrite ingestion in a suicide attempt. The patient presented with cyanosis, hypotension, and elevated methemoglobin levels (64.1%). After poison control consultation, activated charcoal and methylene blue were administered, resulting in rapid clinical improvement and normalization of methemoglobinemia. This case emphasizes the importance of early recognition and treatment of sodium nitrite poisoning, highlighting the life-saving role of methylene blue.

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Publication Details

Journal
Annals of Internal Medicine Clinical Cases
Published
2025-05-01
DOI
https://doi.org/10.7326/aimcc.2024.1277
Primary Topic
Methemoglobinemia and Tumor Lysis Syndrome
Type
article
Field-Weighted Citation Impact
0.00
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article

Intentional Nitrite Ingestion: Clinical Presentation and Emergency Management in a Young Female Patient

Paméla Baldin, Ernani Savini, Michele Domenico Spampinato, Benedetta Perna et al.
Annals of Internal Medicine Clinical Cases
Methemoglobinemia and Tumor Lysis Syndrome
article

Intentional Nitrite Ingestion: Clinical Presentation and Emergency Management in a Young Female Patient

Paméla Baldin, Ernani Savini, Michele Domenico Spampinato, Benedetta Perna, Roberto De Giorgio, Samantha Eichner, Matteo Guarino, Giacomo Maroncelli, Chiara Pesci, Francesca Cuoghi
article en

Abstract

Sodium nitrite (NaNO₂) is an inorganic salt used in food preservation and industrial products, recently implicated in self-harm due to its easy online availability. We report a case of severe methemoglobinemia in a 20-year-old woman following sodium nitrite ingestion in a suicide attempt. The patient presented with cyanosis, hypotension, and elevated methemoglobin levels (64.1%). After poison control consultation, activated charcoal and methylene blue were administered, resulting in rapid clinical improvement and normalization of methemoglobinemia. This case emphasizes the importance of early recognition and treatment of sodium nitrite poisoning, highlighting the life-saving role of methylene blue.

Annals of Internal Medicine Clinical CasesVol. 4(5)
University of Ferrara (IT)
Openalex Percentile: Top 85%
Methemoglobinemia and Tumor Lysis Syndrome
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