Cerebrospinal fluid proteome profiling across the Alzheimer’s disease continuum: a step towards solving the equation for ‘X’
Our study identified proxies of Aβ and tau pathology, indexed by PET, (SMOC1, YWHAE, CNN3) and highlighted the dynamic fluctuations of the CSF proteome over the disease course, identifying candidate biomarkers for disease staging beyond Aβ and tau.
Authors
- Joseph Therriault (ORCID: https://orcid.org/0000-0002-7826-4781)
- Joel Simrén (ORCID: https://orcid.org/0000-0001-5081-6604)
- Fernando González‐Ortiz (ORCID: https://orcid.org/0000-0001-7897-9456)
- Sophia Weiner (ORCID: https://orcid.org/0009-0000-2298-220X)
- Tuomas Rauramaa (ORCID: https://orcid.org/0000-0002-2250-327X)
- Ville Leinonen (ORCID: https://orcid.org/0000-0002-4282-4687)
- Nesrine Rahmouni (ORCID: https://orcid.org/0009-0004-3081-8468)
- Mathias Sauer
- Stijn Servaes (ORCID: https://orcid.org/0000-0002-4431-957X)
- Laia Montoliu‐Gaya (ORCID: https://orcid.org/0000-0001-7684-6318)
- Cécile Tissot (ORCID: https://orcid.org/0000-0003-2711-3833)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Johan Gobom
- Nicholas J. Ashton
- Mikko Hiltunen
- Andréa L. Benedet
- Jenna Stevenson (ORCID: https://orcid.org/0000-0003-2848-1451)
- Kaj Blennow
Institutions
- University of Science and Technology of China (CN)
- Montreal Neurological Institute and Hospital (CA)
- University of Wisconsin–Madison (US)
- University of Arizona (US)
- University of Eastern Finland (FI)
- Sahlgrenska University Hospital (SE)
- McGill University Health Centre (CA)
- Sorbonne Université (FR)
- Kuopio University Hospital (FI)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Institut du Cerveau (FR)
- University College London (GB)
- McGill University (CA)
- University of Gothenburg (SE)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s13024-025-00841-0
- Citations
- 4
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- EU Joint Programme – Neurodegenerative Disease Research
- European Partnership on Metrology
- Hjärnfonden
- Vetenskapsrådet
- Göteborgs Universitet
- Sigrid Juséliuksen Säätiö
- UK Dementia Research Institute
- HORIZON EUROPE Marie Sklodowska-Curie Actions
- HORIZON EUROPE Reforming and enhancing the European Research and Innovation system