Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV
Young Thai men with AHI demonstrated greater WMH progression than PWoH over 2 years despite ART initiation and viral suppression. These data suggest that brain white matter is vulnerable to HIV during early infection, independent from vascular comorbidities or lifestyle factors. Limitations include homogeneity in sex and ethnicity and follow-up period limited to 24 months.
Authors
- Phillip Chan (ORCID: https://orcid.org/0000-0002-4071-4409)
- Sandhya Vasan (ORCID: https://orcid.org/0000-0002-6378-6288)
- Suwanna Puttamaswin
- Carlo Sacdalan (ORCID: https://orcid.org/0000-0002-5839-4837)
- Victor Valcour (ORCID: https://orcid.org/0000-0003-1981-4832)
- Kathryn B. Holroyd (ORCID: https://orcid.org/0000-0001-5884-9734)
- Somchai Sriplienchan
- Mantana Pothisri
- Netsiri Dumrongpisutikul (ORCID: https://orcid.org/0000-0003-1294-7763)
- Robert Paul (ORCID: https://orcid.org/0000-0003-4225-6103)
- Lydie Trautmann (ORCID: https://orcid.org/0000-0002-3012-0009)
- Serena Spudich (ORCID: https://orcid.org/0000-0001-6032-3950)
- Jacob Bolenzius
- Pathariya Promensa
- Pom Sailasuta
Institutions
- Henry M. Jackson Foundation (US)
- Chulalongkorn University (TH)
- University of California, San Francisco (US)
- University of Missouri–St. Louis (US)
- Columbia University Irving Medical Center (US)
- Yale Cancer Center (US)
- Yale University (US)
- Center for Neurosciences (US)
- Walter Reed Army Institute of Research (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1212/wnl.0000000000213591
- Citations
- 4
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 9.01