Sustained Effectiveness of Doxycycline Post-Exposure-Prophylaxis in a Large Sexual Health Clinic Over 96 Weeks: An Interrupted Time Series Analysis
Doxycycline post-exposure prophylaxis (doxy-PEP) reduced bacterial sexually transmitted infection (STI) incidence in a sexual health clinic over 96 weeks (n=4,592; 2,524 on doxy-PEP), particularly for chlamydia and syphilis, with smaller effects for gonorrhea. Continued surveillance for gonorrhea and antibiotic resistance is essential to evaluate doxy-PEP's long-term effectiveness.
Authors
- Matthew A. Spinelli (ORCID: https://orcid.org/0000-0001-6368-8664)
- Susan Buchbinder (ORCID: https://orcid.org/0000-0003-2404-0712)
- Megan J. Heise (ORCID: https://orcid.org/0000-0001-6651-2381)
- James Bena (ORCID: https://orcid.org/0000-0002-7592-0480)
- Jorge Román (ORCID: https://orcid.org/0000-0002-3346-1597)
- Hyman M Scott (ORCID: https://orcid.org/0000-0001-8775-7214)
- Michael P. Barry (ORCID: https://orcid.org/0000-0003-4878-1208)
Institutions
- University of California, San Francisco (US)
- San Francisco AIDS Foundation (US)
- San Francisco Department of Public Health (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1093/cid/ciaf234
- Citations
- 3
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 3.55