Algebraic differentiation for fast sensitivity analysis of optimal flux modes in metabolic models
Software introduced here is available as open-source Julia packages DifferentiableMetabolism.jl (https://github.com/stelmo/DifferentiableMetabolism.jl) and ElementaryFluxModes.jl (https://github.com/HettieC/ElementaryFluxModes.jl), which both work on all major operating systems and computer architectures. Code to reproduce all results is available from https://github.com/HettieC/DifferentiableOFMPaper, and as an archive from https://doi.org/10.5281/zenodo.15183208.
Authors
- Henry N. Chapman (ORCID: https://orcid.org/0000-0002-4655-1743)
- St. Elmo Wilken (ORCID: https://orcid.org/0000-0002-4113-2590)
- Oliver Ebenhöh (ORCID: https://orcid.org/0000-0002-7229-7398)
- Miroslav Kratochvíl (ORCID: https://orcid.org/0000-0001-7356-4075)
Institutions
- University of Luxembourg (LU)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Bioinformatics
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1093/bioinformatics/btaf287
- Primary Topic
- Microbial Metabolic Engineering and Bioproduction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Copenhagen Graduate School for Nanoscience and Nanotechnology