A Prospective Evaluation of a Three-Gene Host Response Signature to Classify Tuberculosis Severity in Children
Xpert-HR approached the target accuracy to stratify PTB severity in older children and those with Confirmed TB but had lower specificity in children with Unconfirmed TB. Child-specific signatures may be needed to improve performance in younger children with paucibacillary disease.
Authors
- Jascent Nakafeero
- Alfred Andama (ORCID: https://orcid.org/0000-0003-0526-0007)
- Esin Nkereuwem
- Devan Jaganath (ORCID: https://orcid.org/0000-0002-8555-5667)
- Moses Nsereko
- Peter Wambi (ORCID: https://orcid.org/0000-0002-9195-0778)
- Brittney Sweetser (ORCID: https://orcid.org/0000-0001-8655-2639)
- Beate Kampmann (ORCID: https://orcid.org/0000-0002-6546-4709)
- Adithya Cattamanchi (ORCID: https://orcid.org/0000-0002-6553-2601)
- Marie P Gomez
- Eric Wobudeya (ORCID: https://orcid.org/0000-0001-9574-5539)
- J. Ernst (ORCID: https://orcid.org/0000-0001-9951-6207)
Institutions
- University of California, San Francisco (US)
- University of California, Irvine Medical Center (US)
- MRC Unit the Gambia (GM)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Global Brain Health Institute (US)
- University of San Francisco (US)
Publication Details
- Journal
- Journal of the Pediatric Infectious Diseases Society
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1093/jpids/piaf041
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health