Hydrogen Sulfide Alleviates Lipid Peroxidation-Mediated Carbonyl Stress in Uranium-Intoxicated Kidney Cells <i>via</i> Nrf2/ARE Signaling.
H <sub>2</sub>S induces Nrf2 activation and nuclear translocation, which modulates the expression of aldehyde-metabolizing enzymes and the CBS/H <sub>2</sub>S axis. Simultaneously, the Nrf2-controlled CBS/H <sub>2</sub>S axis may at least partially promote Nrf2 activation and nuclear translocation. These events form a cycle-regulating mode through which H <sub>2</sub>S attenuates the carbonyl stress-mediated NRK-52E cytotoxicity triggered by uranium.
Authors
- Ji-Ren Zheng
- Min Wang
- Rui Zhang (ORCID: https://orcid.org/0000-0002-8664-6915)
- Qiao Hu (ORCID: https://orcid.org/0000-0003-1996-0194)
- Xi Jiang (ORCID: https://orcid.org/0000-0003-1932-442X)
- Jia Lin Liu
Institutions
- Guilin Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-04-20
- DOI
- https://doi.org/10.3967/bes2025.021
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00