Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling
<i>SIRT4</i> overexpression accelerates heart failure development in response to pressure overload, predominantly by ROS-mediated enhancement of profibrotic transcriptional signaling.
Authors
- Dirk von Lewinski (ORCID: https://orcid.org/0000-0001-9996-6128)
- Christoph Bode
- Andreas Zirlik (ORCID: https://orcid.org/0000-0001-6290-3297)
- Senka Ljubojević-Holzer (ORCID: https://orcid.org/0000-0001-6994-9976)
- Katharina Pfeil
- Peter P. Rainer (ORCID: https://orcid.org/0000-0002-2840-6454)
- Ivan Vosko (ORCID: https://orcid.org/0000-0002-6198-888X)
- Michael M. Hoffmann (ORCID: https://orcid.org/0000-0001-8459-6080)
- Johannes Gollmer (ORCID: https://orcid.org/0000-0002-8734-6359)
- Dennis Wolf (ORCID: https://orcid.org/0000-0003-1525-4348)
- Christoph Koentges (ORCID: https://orcid.org/0000-0002-2074-7182)
- Douglas S. Scherr (ORCID: https://orcid.org/0000-0001-5868-5493)
- Günter Roth (ORCID: https://orcid.org/0000-0001-9343-6046)
- Harald Sourij (ORCID: https://orcid.org/0000-0003-3510-9594)
- Luke Potter (ORCID: https://orcid.org/0000-0002-1736-2898)
- Elaine M. Khan
- Sayan Bakshi (ORCID: https://orcid.org/0000-0002-6717-6049)
- Markus Wallner (ORCID: https://orcid.org/0000-0001-7692-892X)
- Robert Săndulescu
- Hauke Horstmann (ORCID: https://orcid.org/0000-0002-9971-1800)
- Katja E. Odening (ORCID: https://orcid.org/0000-0001-6999-841X)
- Simon Sedej (ORCID: https://orcid.org/0000-0002-4419-6821)
- Adam R. Wende (ORCID: https://orcid.org/0000-0002-5536-4675)
- Nikole J. Byrne (ORCID: https://orcid.org/0000-0002-0006-7147)
- Heiko Bugger (ORCID: https://orcid.org/0000-0002-3524-0405)
- Thomas Rathner
- Carolin Költgen
Institutions
- University of Freiburg (DE)
- Medical University of Graz (AT)
- University of Maribor (SI)
- BioTechMed-Graz (AT)
- Universitätsklinikum Würzburg (DE)
- Zentrum für Psychiatrie Emmendingen (DE)
Publication Details
- Journal
- Journal of Molecular and Cellular Cardiology Plus
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1016/j.jmccpl.2025.100299
- Citations
- 3
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 3.67
Funders
- American Heart Association
- Deutsche Forschungsgemeinschaft
- Austrian Science Fund
- Peter und Traudl Engelhorn Stiftung
- National Institutes of Health
- National Institute of Nursing Research