Genome Announcement of Four Parechovirus A3 Isolates from the United States of America
We report the complete genome sequences of four parechovirus-A3 (PeV-A3) isolates from Children's Mercy Kansas City (CMKC), United States of America (USA): PeV-A3-MO-12-CMKC/CSF/MO/USA/2012 (isolated in 2012 from cerebrospinal fluid), PeV-A3-8C-CMKC/CSF/MO/USA/2022/ (isolated in 2022 from cerebrospinal fluid), PeV-A3-9C-CMKC/CSF/MO/USA/2022 (isolated in 2022 from cerebrospinal fluid), and PeV-A3-11B-CMKC/Blood/MO/USA/2022 (isolated in 2022 from blood). Sequence analysis revealed multiple mutations throughout the genome of the PeV-A3 isolates in comparison to the prototypic PeV-A3 A308/99 reference sequence (AB084913). Several unique amino acid changes were observed in the PeV-A3 isolates from 2022 that were absent in the PeV-A3 isolate from 2012. Phylogenetic analysis comparison determined that the sequenced PeV-A3 isolates from 2022 cluster together as a separate clade.
Authors
- Eric Rhoden (ORCID: https://orcid.org/0000-0001-8642-9948)
- Bernardo A. Mainou (ORCID: https://orcid.org/0000-0002-7721-183X)
- Christopher J. Harrison (ORCID: https://orcid.org/0000-0003-4281-1824)
- Anjana Sasidharan (ORCID: https://orcid.org/0009-0008-7559-1796)
- Rangaraj Selvarangan (ORCID: https://orcid.org/0000-0003-3275-6657)
- Terry Fei Fan Ng (ORCID: https://orcid.org/0000-0002-4815-8697)
- Debarpan Dhar (ORCID: https://orcid.org/0000-0002-6776-5089)
- Katelyn E. VanDonge
- Varun Chandra Boinpelly
Institutions
- Centers for Disease Control and Prevention (US)
- Mercy Research (US)
- University of Missouri–Kansas City (US)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2025-05-05
- DOI
- https://doi.org/10.3390/ijms26094378
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00