Peripheral T lymphocyte immune characteristics dictate response to transarterial chemoembolization in unresectable hepatocellular carcinoma
Our study demonstrated significant differences in the immune characteristics of peripheral T lymphocytes between the Non-Response and Response groups. The CD8<sup>+</sup> T<sub>SCM</sub> and CD8<sup>+</sup> T<sub>Senescence</sub> subsets are potential predictors of TACE efficacy and long-term survival. These insights into peripheral blood T lymphocytes offer valuable evidence to help clinicians more effectively identify potential TACE-responsive populations, predict survival, and develop personalized treatment regimens for patients with uHCC.
Authors
- Huan Chen (ORCID: https://orcid.org/0000-0002-6032-6569)
- Shengwang Zhang
- Pengfei Rong (ORCID: https://orcid.org/0000-0001-5473-1982)
- Wei Wang (ORCID: https://orcid.org/0000-0001-6853-7785)
- Xiaoqian Ma
- Qi Liang (ORCID: https://orcid.org/0000-0002-0054-1478)
- Huaping Liu (ORCID: https://orcid.org/0000-0002-1434-7553)
- Lei Peng (ORCID: https://orcid.org/0009-0002-6190-9296)
Institutions
- Central South University (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Therapeutic Advances in Gastroenterology
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1177/17562848251333295
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hunan Province