Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study
Our findings suggest that mGluR5 reduction in AD is closely linked to synaptic loss. Longitudinal studies are needed to clarify causality, deepen understanding of AD pathogenesis, and aid in developing novel biomarkers and treatments.
Authors
- Nabeel Nabulsi (ORCID: https://orcid.org/0000-0001-8129-0051)
- Richard E. Carson (ORCID: https://orcid.org/0000-0002-9338-7966)
- Yiyun Huang (ORCID: https://orcid.org/0000-0001-5269-3775)
- Christopher H van Dyck
- Ryan S. O’Dell (ORCID: https://orcid.org/0000-0001-7673-6661)
- Elaheh Salardini
- Adam P. Mecca (ORCID: https://orcid.org/0000-0003-1982-5443)
- Em Tchorz
Institutions
- Yale University (US)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s13195-025-01739-1
- Citations
- 3
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Yale University
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- National Institute on Aging
- National Center for Advancing Translational Sciences