Hemoglobin During Pregnancy Does Not Mediate the Relationship between Nutrition Supplements and Intrauterine Growth: A Secondary Data Analysis of Women First Preconception Nutrition Trial
The observed main effect of multiple micronutrient-fortified SQ-LNS on intrauterine growth was not mediated by Hb levels at 12 or 32 wk of gestation. The findings suggest exploring other pathways implicated in the association between the SQ-LNS and intrauterine growth. This trial was registered at clinicaltrials.gov as #NCT01883193 (https://clinicaltrials.gov/ct2/show/NCT01883193?term=01883193&rank=1).
Authors
- Sarah Saleem (ORCID: https://orcid.org/0000-0002-6797-8631)
- Jamie Westcott (ORCID: https://orcid.org/0000-0002-0549-3145)
- Sangappa Dhaded (ORCID: https://orcid.org/0000-0001-9575-5251)
- Jeanine M. Genkinger (ORCID: https://orcid.org/0000-0002-8438-0412)
- Nancy F. Krebs (ORCID: https://orcid.org/0000-0001-5652-7547)
- Lester Figueroa (ORCID: https://orcid.org/0000-0003-1732-0361)
- Antoinette Tshefu (ORCID: https://orcid.org/0000-0001-7657-6901)
- Richard J. Derman (ORCID: https://orcid.org/0000-0003-1148-1594)
- Elizabeth M. McClure (ORCID: https://orcid.org/0000-0001-8659-5444)
- Melissa Bauserman (ORCID: https://orcid.org/0000-0002-4992-9895)
- Louise Kuhn (ORCID: https://orcid.org/0000-0002-2305-8665)
- Shivaprasad S. Goudar (ORCID: https://orcid.org/0000-0002-8680-7053)
- M. Thomas (ORCID: https://orcid.org/0000-0002-2358-9204)
- Adrien Lokangaka (ORCID: https://orcid.org/0000-0002-8609-5877)
- Sumera Aziz Ali (ORCID: https://orcid.org/0000-0001-8996-7995)
- Linda Valeri (ORCID: https://orcid.org/0000-0003-0664-1194)
- Saleem Jessani (ORCID: https://orcid.org/0000-0003-3025-2025)
- Ana L. Garcés
- Robert L. Goldenberg
- Jennifer F Kemp
- Ka Kahe
Institutions
- University of North Carolina at Chapel Hill (US)
- Aga Khan University (PK)
- Ministry of Public Health (CD)
- Harvard University (US)
- Thomas Jefferson University (US)
- University of Alberta (CA)
- RTI International (US)
- Columbia University Irving Medical Center (US)
- Jawaharlal Nehru Medical College (IN)
- Institute of Nutrition of Central America and Panama (GT)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- University of Colorado Anschutz Medical Campus (US)
- Columbia University (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of Nutrition
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1016/j.tjnut.2025.04.036
- Primary Topic
- Child Nutrition and Water Access
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Office of Dietary Supplements
- Bill and Melinda Gates Foundation
- Eunice Kennedy Shriver National Institute of Child Health and Human Development