The Neuropsychiatric Role of Platelets: Insights into Anxiety and Depression

Anxiety disorders are among the most prevalent mental illnesses, and their incidence is rising globally. The size, volume, and functions of platelets may vary because of generalized anxiety disorder, and mental stress makes platelets more aggregable. An increase in platelet volume and activity is often brought on by stress and anxiety via a variety of mechanisms. In individuals with a generalized anxiety disorder (GAD), the alterations in platelet indices may thereby increase their chance of developing thrombotic disorders in the future. Since people with generalized anxiety disorder have much greater mean platelet volumes, platelet distribution widths, and platelet crits than healthy adults, it might be inferred that they may be more susceptible to thrombotic disorders. In this review, we focused on the prevalence of anxiety and depression in teenagers and the role of platelets in anxiety and depression.