A Series of Personalized Melatonin Supplement Interventions for Poor Sleep: Feasibility Randomized Crossover Trial for Personalized N-of-1 Treatment
Participant ratings of the usability of and satisfaction with this series of personalized N-of-1 trials of melatonin for sleep suggest these trials are both feasible and acceptable. However, our results show that melatonin supplements did not significantly improve sleep duration or sleep quality. Furthermore, the treatment effects' lack of heterogeneity among participants suggests that future use of N-of-1 trials of melatonin for poor sleep is not needed.
Authors
- Danielle Miller (ORCID: https://orcid.org/0000-0002-0102-1263)
- Thevaa Chandereng (ORCID: https://orcid.org/0000-0003-4078-9176)
- Alexandra Perrin (ORCID: https://orcid.org/0000-0002-9099-2482)
- Heejoon Ahn (ORCID: https://orcid.org/0000-0003-4938-4909)
- Jordyn Rodillas (ORCID: https://orcid.org/0009-0009-9630-1468)
- Mark Butler (ORCID: https://orcid.org/0000-0003-4359-2897)
- Karina W. Davidson (ORCID: https://orcid.org/0000-0002-9162-477X)
- Ashley M. Goodwin (ORCID: https://orcid.org/0000-0003-4206-0979)
- Ying Kuen Cheung (ORCID: https://orcid.org/0000-0001-8530-035X)
- Ciarán P Friel (ORCID: https://orcid.org/0000-0001-9882-2851)
- Stefani D’Angelo (ORCID: https://orcid.org/0000-0002-3590-8284)
Institutions
- Northwell Health (US)
- Feinstein Institute for Medical Research (US)
- Columbia University (US)
Publication Details
- Journal
- JMIR Formative Research
- Published
- 2025-05-05
- DOI
- https://doi.org/10.2196/58192
- Citations
- 1
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.12