Differential effects of tofacitinib on macrophage activation contribute to lack of response in ulcerative colitis patients

We conclude that resistance to tofacitinib is mediated by the hyperactivation of myeloid cells and we identify IL-10-dependent macrophages as one cellular subset contributing to this resistance.

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Publication Details

Journal
Journal of Crohn s and Colitis
Published
2025-05-05
DOI
https://doi.org/10.1093/ecco-jcc/jjaf076
Citations
7
Primary Topic
Inflammatory Bowel Disease
Type
article
Field-Weighted Citation Impact
12.72

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article

Differential effects of tofacitinib on macrophage activation contribute to lack of response in ulcerative colitis patients

E Ricart, Marisol Veny, Manel Esteller, Maria Carme Masamunt et al.
7 citations
Journal of Crohn s and Colitis
Inflammatory Bowel Disease
12.72
article

Differential effects of tofacitinib on macrophage activation contribute to lack of response in ulcerative colitis patients

E Ricart, Marisol Veny, Manel Esteller, Maria Carme Masamunt, Severine A.R.A. Vermeire, Elisa Melón-Ardanaz, Bram Verstockt, Azucena Salas, Julián Panés, Berta Caballol, A M Corraliza, Victòria Gudiño, Marta Gallego, Alba Garrido-Trigo, A Fernández-Clotet, Ángel L. Corbí, Íngrid Ordás, Ángela Sanzo-Machuca, Maria Teresa Rodrigo‐Calvo, À Giner, Marc Buendia, Lisseth Robbins-Moreno
article en
7 citations

Abstract

We conclude that resistance to tofacitinib is mediated by the hyperactivation of myeloid cells and we identify IL-10-dependent macrophages as one cellular subset contributing to this resistance.

Journal of Crohn s and ColitisVol. 19(6)
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES), Centro de Investigaciones Biológicas Margarita Salas (ES), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), KU Leuven (BE)
Pfizer, European Federation of Pharmaceutical Industries and Associations, European Commission, KU Leuven, Ministerio de Ciencia e Innovación, Universitat de Barcelona, Universitaire Ziekenhuizen Leuven, KU Leuven
Good health and well-being
Openalex Percentile: Top 1%
Inflammatory Bowel Disease
12.72
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