Inhibition of TLR4 mitigates sensorineural hearing loss resulting from cochlear inflammation
LPS injection into the PSCC induces sensorineural tissue damage in the cochlea and results in sensorineural hearing loss. These findings suggest that TLR4 inhibition can alleviate cochlear inflammation-induced sensorineural hearing loss. TLR4 represents a potential therapeutic target for sensorineural hearing loss.
Authors
- Jintao Lou (ORCID: https://orcid.org/0009-0005-3209-8211)
- Zhenxuan Zhao (ORCID: https://orcid.org/0000-0001-8006-8192)
- Zhigang Zhang (ORCID: https://orcid.org/0000-0001-9624-9668)
- Yi‐Si Feng (ORCID: https://orcid.org/0000-0002-1646-0955)
- Wuhui He (ORCID: https://orcid.org/0000-0001-6821-5639)
- Jia Guo (ORCID: https://orcid.org/0000-0002-9110-5574)
- Fan Wu
- Yu Si (ORCID: https://orcid.org/0009-0004-8925-7263)
- Yan Huang (ORCID: https://orcid.org/0000-0002-8021-8055)
- Wei Liu (ORCID: https://orcid.org/0009-0002-1621-3505)
- Rui Hu (ORCID: https://orcid.org/0000-0002-5081-2256)
- Jingman Deng
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1186/s10020-025-01219-0
- Citations
- 3
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 4.39
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Natural Science Foundation of Guangdong Province