CDK4/6 Inhibitors-Induced Macrocytosis Is Not Associated with Hemolysis and Does Not Impact Hemoglobin Homeostasis
These findings suggest that, despite changes in RBC volume, CDK4/6is do not predispose patients to RBC destruction and do not impair regulation of hemoglobin homeostasis. We show that CDK4/6is do not decrease the RBC lifespan in pre-treatment erythrocytes. Unfortunately, this method cannot determine the lifespan of post-treatment RBCs, but further research could help answer this question.
Authors
- Carolina Monteiro
- Miguel Esperança‐Martins (ORCID: https://orcid.org/0000-0002-6858-7341)
- Inês Soares de Pinho (ORCID: https://orcid.org/0000-0002-8377-0179)
- Vanessa Pérez (ORCID: https://orcid.org/0000-0003-0586-3019)
- Leila Costa
- Luís Costa (ORCID: https://orcid.org/0000-0002-4782-7318)
- Gonçalo Nogueira-Costa (ORCID: https://orcid.org/0000-0002-1127-052X)
- Lisa Gonçalves (ORCID: https://orcid.org/0000-0002-3431-5217)
- Tiago Barroso
- Helena Luna Pais (ORCID: https://orcid.org/0000-0001-7666-1890)
- Sofía Torres (ORCID: https://orcid.org/0000-0001-6108-6918)
- João Araújo (ORCID: https://orcid.org/0000-0002-8558-6762)
- Rita Sousa (ORCID: https://orcid.org/0000-0002-9147-7896)
- Leonor Ribeiro (ORCID: https://orcid.org/0000-0002-7657-0902)
- Catarina Abreu
Institutions
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
Publication Details
- Journal
- Cancers
- Published
- 2025-05-05
- DOI
- https://doi.org/10.3390/cancers17091567
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00